Friday, January 5, 2018

Some other locations of neuroglobin

Two posts ago, I mentioned that there appears to be a non-canonical H2S oxidation pathway involving human ferric neuroglobin. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5486136/) Neuroglobin is high in the brain and also might be upregulated by hypoxia in the stomach fundus and the small intestine. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2945342/) As I was looking into neuroglobin, I noticed that it is also highly expressed in the adrenal glands, pancreas, and testis. (https://www.ncbi.nlm.nih.gov/gene/58157)

If my idea is correct about neuroglobin being involved in causing an excess amount of sulfite to result from H2S catabolism--which sulfite then causes migraine symptoms in the brain and nausea/vomiting in the stomach/proximal small intestine--then there could also be hard-to-explain, individually-varying, molybdenum-deficiency-linked illnesses involving those other parts of the body, similar to migraine and "morning sickness." There certainly is a weird illness happening for some in their pancreases: idiopathic chronic pancreatitis (https://www.medscape.com/viewarticle/487185). Maybe molybdenum could help with idiopathic chronic pancreatitis; at the very least, it wouldn't hurt to try it for the nausea and vomiting that often occur during episodes of pain. (https://www.medicalnewstoday.com/articles/160459.php) I have no idea about the adrenal glands and the testis, though. I don't know anyone who has issues with those body parts (at least openly), and I usually confine my research to something I can ask a friend/relative about in order to ground my hypothesizing to reality.

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